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CVS Caremark e-Prescribing Tool Helps Healthcare Professionals Identify and Assess Impact of Medication Noncompliance
    Data to be Presented in Conjunction with Horizon Blue Cross Blue
   Shield of New Jersey at the 20th Annual Meeting of the Academy of
           Managed Care Pharmacy (AMCP) in San Francisco, CA

WOONSOCKET, R.I.--(BUSINESS WIRE)--April 17, 2008--CVS Caremark (NYSE: CVS) and Horizon Blue Cross Blue Shield of New Jersey, (Horizon BCBSNJ) will be presenting data on Friday, April 18th at the twentieth annual meeting of the Academy of Managed Care Pharmacy (AMCP), which demonstrates how the iScribe(R) e-prescribing tool can allow for the objective identification and assessment of medication noncompliance to enable appropriate patient intervention. The study, conducted in conjunction with Horizon BCBSNJ, analyzed when and if prescriptions written for the treatment of various chronic conditions, such as cardiovascular disease, were dispensed to patients.

Study results found a high rate of noncompliance among all patients taking medications to treat a variety of cardiovascular diseases such as high blood pressure, with approximately 18% of those prescriptions unfilled after 60 days. Patients continuing their therapy were found to be significantly more compliant than those starting a new therapy with a cardiovascular medication. Noncompliance among patients continuing therapy was approximately 6%, while noncompliance rates for patients initiating therapy with a cardiovascular medication (i.e., primary noncompliance) were much higher, with up to 70% of patients noncompliant after 60 days.

"While it is widely recognized that medication noncompliance contributes to adverse drug events, poor health outcomes and increased healthcare costs, research to date has focused on patients who discontinue therapy and has not been able to account for primary noncompliance, where medications prescribed to begin therapy are never filled by the patient," said Jan E. Berger, MD, Chief Clinical Officer, CVS Caremark Corporation. "The data, collected using iScribe e-prescribing technology, shows us not only that there is an extremely high rate of primary noncompliance for medications to treat cardiovascular conditions, which places patients at increased risk for heart attack or stroke, but also provides information that can help shape how and when healthcare providers can most effectively intervene with education and support."

"e-Prescribing tools like iScribe can ultimately provide physicians with concrete information about whether or not a patient actually initiates a new therapy," said Richard G. Popiel, MD, MBA, Vice President and Chief Medical Officer, Horizon BCBSNJ. "This type of information can help physicians, nurses and pharmacists understand the optimal timing and delivery for interventions and educational outreach to ensure patients take the medications that can help keep them healthy."

Data was collected between January 1, 2005 and October 31, 2006 from a subset of 507 Horizon BCBSNJ providers who use iScribe e-prescribing technology. Researchers conducted a retrospective analysis comparing prescriptions for medications to treat chronic diseases (i.e., asthma, cardiovascular diseases, and diabetes) as well as prescriptions for antibiotics written via iScribe during this time period to submitted drug claims for medications dispensed between January 1, 2005 and December 31, 2006.

"CVS Caremark is focused on improving patient outcomes, including compliance and adherence to medications, especially for chronic diseases such as cardiovascular conditions, diabetes and asthma," said Dr. Berger. "The data we can obtain through e-prescribing enables us to work in conjunction with a patient's physician to address medication noncompliance earlier and encourage patients to take their medications as needed either via phone call, mail or face-to-face counseling at the pharmacy counter."

A poster presentation on this study will take place during the twentieth Annual AMCP meeting on Friday, April 18th from 12:00 - 2:00 pm in West Hall, Level I at the Moscone West Convention Center in San Francisco, CA.

About iScribe e-Prescribing

iScribe is an intuitive, easy-to-use e-Prescribing product that prescribers report they can begin using within 15 to 30 minutes of picking up their PDA. With iScribe, prescribers can send prescriptions securely and directly to the patient's pharmacy of choice from either a handheld PDA or desktop computer. iScribe provides the prescriber with generic and formulary coverage information, assisting the physician in selecting the most cost-effective medication for their patients. Physicians can use the electronic prescribing tools to write prescriptions for all of their patients, regardless of the patient's prescription benefit coverage. Physicians can check for potentially harmful drug interactions at the point of prescribing, or follow-up with patients when iScribe alerts them to unfilled prescriptions. The convenience of a mobile device ensures patient prescriber history is with them at all times - either in the office or when the prescriber is on-call. iScribe electronic prescribing helps to reduce phone calls and faxes between the practice and the pharmacy, improve patient safety and drive better medication compliance.

About CVS Caremark

CVS Caremark is the largest provider of prescriptions and related health care services in the nation. The Company fills or manages more than 1 billion prescriptions annually. Through its unmatched breadth of service offerings, CVS Caremark is transforming the delivery of health care services in the U.S. The Company is uniquely positioned to effectively manage costs and improve health care outcomes through its 6,300 CVS/pharmacy stores; its pharmacy benefit management, mail order and specialty pharmacy division, Caremark Pharmacy Services; its retail-based health clinic subsidiary, MinuteClinic; and its online pharmacy, General information about CVS Caremark is available through the Investor Relations portion of the Company's website, at, as well as through the pressroom portion of the Company's website, at

About Horizon Blue Cross Blue Shield of New Jersey

Horizon Blue Cross Blue Shield of New Jersey is the oldest and largest health insurer in the state serving over 3.5 million members. Horizon BCBSNJ is New Jersey's only not-for-profit, health service corporation and is headquartered in Newark with offices in Wall, Mt. Laurel, and West Trenton.

Horizon BCBSNJ provides a broad array of health and dental insurance products and services for individuals and small and large companies, including national companies headquartered in New Jersey. Horizon BCBSNJ is committed to improving the health care experience for all the communities we serve as well as helping our members become and stay healthy.

Horizon BCBSNJ's Web site is located at Horizon BCBSNJ is an independent licensee of the Blue Cross Blue Shield Association.

    CONTACT: Weber Shandwick
             Lee-Anne Murphy, 617-755-8684
             CVS Caremark
             Christine Cramer, 401-770-3317
             Horizon BCBSNJ
             Daniel Emmer, 973-466-4805

    SOURCE: CVS Caremark

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